Aleve, Vioxx, Celebrex, and Bextra: What You Need To Know About Arthritis Pain Medications

Recent controversy about the safety of pain medications for arthritis has left patients and health care professionals alike confused about which medications are safe to use. In fact, a recent survey by the Boston-based Rippe Lifestyle Institute indicated that many people with arthritis are suffering unnecessarily because they have stopped or reduced their use of pain relievers due to confusion about which drugs are considered safe.

The survey also showed that now, more than ever, those with arthritis need to understand the benefits and possible side effects associated with all arthritis pain medications. In order to do so, people with arthritis, their caregivers and families must be familiar with recent news about the two types of drugs most commonly used to treat arthritis pain ? non-selective, non-steroidal anti-inflammatory drugs (NSAIDs), and another group of NSAIDs known as cyclooxygenase-2 (COX-2) specific inhibitors.

COX-2 specific inhibitors vs. Other NSAIDs

COX-2 specific inhibitors are the newest members of the NSAID class of medications. Available by prescription only, they became widely used in recent years to reduce joint pain and swelling. COX-2 specific inhibitors work by selectively blocking, or inhibiting, one of the two enzymes associated with inflammation. Some experts think that this selective inhibition may be one reason for some of the negative side effects currently associated with COX-2 specific inhibitors.

Non-selective NSAIDs were developed earlier than COX-2 specific inhibitors and have been widely used to relieve arthritis pain and inflammation for many years. Unlike COX-2 specific inhibitors, non-selective NSAIDs inhibit both major enzymes involved in the inflammatory process, COX-1 and COX-2. The non-selective NSAID category includes a number of different medications that are available in both prescription and over-the-counter (OTC) products.

Timeline of Events

To understand the current state of affairs, it is important to understand the sequence of events. The controversy started when a study published in the October 21, 2004, issue of the New England Journal of Medicine cited the COX-2 specific inhibitor, Vioxx as potentially causing "major adverse events," including heart attack and stroke, among patients taking the drug. As a result, Merck (the drug's manufacturer) voluntarily withdrew Vioxx from the market. However, in the months following, the safety of the other available COX-2 specific inhibitors such as Celebrex and Bextra, as well as other arthritis pain medications in the non-steroidal anti-inflammatory (NSAID) class, were also called into question.

Consequently, in February 2005, the US Food and Drug Administration (FDA) convened a special Advisory Committee, made up of members of the Arthritis and Drug Safety Advisory Committees, to review the cardiovascular safety of these arthritis pain medications.

FDA Directive: Stronger Warning Labels for Some Pain Medications

On April 7, 2005, taking into account the recommendations of the Advisory Committee, the FDA issued the following directives:

? Bextra, a COX-2 specific inhibitor manufactured by Pfizer, was withdrawn from the market.

? All prescription NSAIDs must revise their labeling to include a "black box" warning that highlights the potential increased risk for cardiovascular (CV) events as well as the potentially life threatening gastrointestinal (GI) bleeding associated with these drugs. Celebrex, the only COX-2 specific inhibitor remaining on the US market, was included in this directive.

? All OTC NSAIDs (except aspirin) will be required to revise their labeling to include more specific information about the potential for GI and CV side effects, a stronger reminder to follow label instructions, as well as a warning about potential skin reactions.

To further evaluate the potential for increased CV risk, the FDA also announced that all NSAIDs must conduct and submit to the FDA a comprehensive review and analysis of pertinent safety data from clinical trials.

? Aleve (naproxen sodium) is supported by clinical studies conducted to gain approval of naproxen as a prescription product and as OTC that do not provide any evidence of increased risk of cardiovascular events.

Treatment Options: What Should Arthritis Patients Know?

For some people who suffer from pain associated with arthritis, their symptoms can be managed with exercise, heat/cold therapy, joint protection, assistive devices, weight control, or in some severe cases, surgery. For others, medications are needed to help manage the symptoms associated with arthritis.

When taken as directed OTC medications such as Aleve provide a safe and effective way to treat mild to moderate pain of minor arthritis. If patients have questions, they should consult their health care professional about which treatment option is most appropriate.

Why It's Important to Treat Arthritis

Arthritis affects approximately 66 million Americans and is the nation's leading cause of disability. There are over 100 different types of arthritis, and they all have different symptoms that vary in severity from person to person. The most common form of arthritis, osteoarthritis, is characterized by the breakdown of cartilage that causes the bones to rub together, resulting in pain, loss of movements and stiffness. Arthritis is usually a chronic condition.

For more information on Aleve and naproxen, visit the Aleve website at www.aleve.com. For more information on arthritis pain relief, visit www.arthritis.org

Please visit http://www.aleve.com for more information.

---

Google News Updated : Wed, 09 Jul 2008 13:08:20 GMT US MBA's Mortgage Applications Index Increased 7.5% Last Week - Bloomberg 100 Mortgages US MBA's Mortgage Applications Index Increased 7.5% Last Week Bloomberg - 1 hour ago By Shobhana Chandra July 9 (Bloomberg) -- Mortgage applications in the US rose for a second straight week, a sign that falling home prices are attracting some buyers. Mortgage applications up 7.5% last week: MBA MarketWatch US mortgage applications increased last week-MBA Reuters CNN - Forbes - RTT News - 100 Mortgages all 15 news articles Publ.Date : Wed, 09 Jul 2008 11:38:08 GMT Polygamist sect leader swaps jail for hospital - MSNBC KVAL Polygamist sect leader swaps jail for hospital MSNBC - 2 hours ago Warren Jeffs, the head of the Fundamentalist Church of Jesus Christ of Latter Day Saints, has been hospitalized. Douglas C. Pizac / Pool via Getty Images FILE July 2: Michael Sean Winters, author of "Left at the Altar," joins the "Morning Joe" crew to ... Jeffs was taken to the Sunrise Hospital and Medical Center in Las ... CNN Warren Jeffs Remains In Local Hospital KXNT Salt Lake Tribune - The Associated Press - Deseret News - Las Vegas Review - Journal all 309 news articles Publ.Date : Wed, 09 Jul 2008 10:48:40 GMT Google adds third dimension to online social relationships - NetworkWorld.com Siliconrepublic.com Google adds third dimension to online social relationships NetworkWorld.com - 2 hours ago By Mikael Ricknäs , IDG News Service , 07/09/2008 Google has entered yet another space with the launch of Lively, a tool for creating 3D social spaces on Web sites, which is now available in a public beta test. Virtual world tipping point: Is there an enterprise use? ZDNet Google Introduces a Cartoonlike Method for Talking in Chat Rooms New York Times Reuters - The Tech Herald - eFluxMedia - Wall Street Journal all 263 news articles Publ.Date : Wed, 09 Jul 2008 11:04:08 GMT Coalition to lobby for US health-care reform - Reuters KULR-TV Coalition to lobby for US health-care reform Reuters - 17 hours ago WASHINGTON, July 8 (Reuters) - A coalition of unions, think tanks and other groups launched an advertising campaign on Tuesday saying they want to ensure that health-care reform tops the US political agenda after the November elections. Coalition begins universal health care campaign Great Falls Tribune Coalition launches push for health care reform Milwaukee Journal Sentinel Rapid City Journal - Tampa Tribune - Beyond Chron - Washington Post all 291 news articles Publ.Date : Tue, 08 Jul 2008 19:09:32 GMT German shares up midday as financials rebound - Forbes ABC News German shares up midday as financials rebound Forbes - 1 hour ago FRANKFURT (Thomson Financial) - German shares were higher midday, led by financials, which rebounded from Tuesday's strong losses, and helped by soothing words from US Federal Reserve Chairman Ben Bernanke and easing oil prices. Fed ready to aid investment banks BBC News Fed Sees Turmoil Persisting Deep Into Next Year New York Times International Herald Tribune - Reuters - Financial Times - CNNMoney.com all 1,484 news articles Publ.Date : Wed, 09 Jul 2008 11:46:08 GMT Iraq Wants Withdrawal Timetable In US Pact - Washington Post ABC News Iraq Wants Withdrawal Timetable In US Pact Washington Post - 8 hours ago By Ernesto Londoño and Dan Eggen BAGHDAD, July 8 -- Iraq's national security adviser said Tuesday that his government would not sign an agreement governing the future role of US troops in Iraq unless it includes a timetable for their withdrawal. Maliki's Withdrawal Card Wall Street Journal Iraqi Officials Still Insisting on Timetable to Withdraw New York Times istockAnalyst.com - AFP - CNN - Xinhua all 1,578 news articles Publ.Date : Wed, 09 Jul 2008 04:41:08 GMT G-8 Conference Tackles Global Warming Treaty - Washington Post BBC News G-8 Conference Tackles Global Warming Treaty Washington Post - 1 hour ago By Michael Abramowitz RUSUTSU, Japan, July 9-- The leaders of the countries most responsible for greenhouse gas emissions pledged Wednesday a shared effort to combat global warming, but developing countries like China and India continued to balk at the ... Bush: 'Significant progress' on climate change The Associated Press Emerging Nations Join G-8 on Climate New York Times Aljazeera.net - CNN International - Bloomberg - Telegraph.co.uk all 2,035 news articles Publ.Date : Wed, 09 Jul 2008 11:20:59 GMT Make Data Feed Websites Amazon Associate Software

PARLOT::Ebooks, Scripts, Websites, and more...

Adsense websites

10 Home Remedies For Arthritis Pain Relief

Your Remedy No. 1 ==============Stretch Gently for Strength and Mobility.When... Read More

Chinese Medicine

Chinese Medicine, over 2000 years old, is an ancient form... Read More

Relafen: A New Drug with an Old Danger

Individuals who regularly take Relafen (nabumetone) or other anti-inflammatory medications,... Read More

Redux Lawyer Discusses Fen-Phen Fad

In the early nineties, Redux was the original miracle diet... Read More

3 Facts Everyone Should Know About Stem Cells

Cord BloodCord Blood is the blood that remains in the... Read More

Emotional Effects of Irritable Bowel Syndrome

Irritable bowel syndrome sufferers often find that they have to... Read More

?Winning the War Against Rheumatoid Arthritis?

RA is a condition that forces half of patients to... Read More

Web Therapy: Enhancing Patient Communication with Web Access

According to Jennifer Lyons' chart, she's just a bad slip... Read More

UltraCET: The Dynamic Duo Of Prescription Pain Control Medications

Remember the last time you stubbed your toe? OUCH! It's... Read More

Medical Billing PDA: 21st Century Convenience for Medical Practices

Medical Billing PDAOne of the first things I notice about... Read More

Over The Counter Drugs: How To Safely Choose The Right Medication

What Medication Can Cure Me?1. Am I expecting a cure?... Read More

A Fresh Start Plan for People With Neck Pain!

"If you have to deal with chronic neck pain, it... Read More

Chicago Drug Rehab: Long Term Help For a Real Recovery

The central location of the city of Chicago has made... Read More

Affordable Drugs: Saving Money by Splitting Pills

One of the least appreciated cost-savers in medical treatment is... Read More

CT and MRI Scans in Neurological Practice: A Quick Overview

Before computed tomographic (CT) scans became available in the 1970s,... Read More

Advanced Surface Ablation

In patients with corneal thickness below a certain minimum, performing... Read More

Benign Tumors Of The Cervix

Endocervical polypsEndocervical polyps are the most common benign neoplasms of... Read More

Considerations in Distance Education for the Medical Assistant Instructor

Medical Assistant distance education is emerging to meet the demands... Read More

Are You Suffering From Addiction?

Many researchers believe that addiction is a behavior that can... Read More

Phenylpropanolamine (PPH) Lawyer: Decongestant Causes Stroke

Phenylpropanolamine, or PPH, used to be an active ingredient in... Read More

Lotronex Lawyer: Lotronex Side Effects Lawsuit

Even in clinical trials, Lotronex displayed a tendency towards causing... Read More

Molluscum Contagiosum Virus (MCV) Treatment Information - But First, What Is Molluscum?

Molluscum contagiosum treatment is certainly possible with the correct treatment... Read More

Stevens-Johnson Syndrome

Stevens Johnson Syndrome (SJS) is a severe and deadly allergic... Read More

Cut Your Prescription Drug Costs Without Having to Buy Foreign Drugs

Save Up to 93% by Asking for a Generic -... Read More

CRP And Your Heart

Monitoring your CRP level is vitally important because it is... Read More